Water promoted 9-fluorenylmethyloxycarbonyl detachment from amino acids in charged microdroplets

Aqueous microdroplets exhibit unique properties and can trigger reactions that do not occur in bulk solution. Herein, we have demonstrated that water, in microdroplets, can reduce the energy barrier for the lone H transfer of 9-fluorenylmethyloxycarbonyl and promote its detachment from the amino group. This strategy works on various amino acids and opens opportunities of aqueous microdroplets in triggering organic reactions.