Can’t drop the MIC(A/B): Preventing stress-ligand shedding to enhance pan-cancer targeting

Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al. 1 Goulding J. Yeh W.I. Hancock B. Blum R. Xu T. Yang B.H. Chang C.W. Groff B. Avramis E. Pribadi M. et al. A chimeric antigen receptor uniquely recognizing MICA/B stress proteins provides an effective approach to target solid tumors. Med. 2023; 4https://doi.org/10.1016/j.medj.2023.04.004 Abstract Full Text Full Text PDF Scopus (2) Google Scholar describe a unique CAR natural killer (NK) cell platform with pan-cancer activity via preservation and recognition of stress ligands on tumor cell membranes. Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al. 1 Goulding J. Yeh W.I. Hancock B. Blum R. Xu T. Yang B.H. Chang C.W. Groff B. Avramis E. Pribadi M. et al. A chimeric antigen receptor uniquely recognizing MICA/B stress proteins provides an effective approach to target solid tumors. Med. 2023; 4https://doi.org/10.1016/j.medj.2023.04.004 Abstract Full Text Full Text PDF Scopus (2) Google Scholar describe a unique CAR natural killer (NK) cell platform with pan-cancer activity via preservation and recognition of stress ligands on tumor cell membranes. A chimeric antigen receptor uniquely recognizing MICA/B stress proteins provides an effective approach to target solid tumorsGoulding et al.MedMay 11, 2023In BriefCancer therapies that distinguish tumors from healthy tissue and mitigate tumor immune escape are highly sought after. Goulding et al. employed a novel stress-ligand targeting system in combination with a multiplexed-engineered stem cell-derived immune cell to overcome these challenges and kill a broad array of tumor types. Full-Text PDF