硼酸
肽
细胞
化学
细胞生物学
生物化学
纳米技术
计算生物学
生物
组合化学
材料科学
出处
期刊:ACS omega
[American Chemical Society]
日期:2024-04-19
卷期号:9 (17): 19051-19056
标识
DOI:10.1021/acsomega.3c09689
摘要
Studying functional protein delivery into live cells is important, ranging from fundamental research to therapeutics. Cell-penetrating peptides (CPPs) are known to deliver proteins with applauded efficacy and have gained importance for applications in protein therapeutics and exploration of versatile cellular mechanisms. The primary aim of the work is to design a CPP as a tool and delivery vehicle for macromolecules, including proteins. In this work, boronic acid-linked cyclic deca arginine (cR10) is reported as an efficient CPP that exhibited 3-fold higher delivery of chemically synthesized ubiquitin (Ub) than pristine cR10-linked Ub, examined with live U2OS cells. As a futuristic plan, an artificial intelligence machine learning-based rationale has been designed and proposed.
科研通智能强力驱动
Strongly Powered by AbleSci AI