IDDF2023-ABS-0290 An inflammatory bowel diseases integrated resources portal (IBDIRP)

Background

To date, research projects on inflammatory bowel disease (IBD, including ulcerative colitis and Crohn's disease) have generated a large amount of data, including literature, single nucleotide polymorphisms (SNPs) data, metagenomics, metabolism, single-cell sequencing data, bioresources, and database. No integrated database that catalogs all research resources on IBD exists currently. We aimed to elaborate an IBD integrated resources portal (IBDIRP) with the most comprehensive resources.

Methods

We have developed an integrated platform providing information about different aspects of IBD research resources like SNP, gene, transcriptomics, microbiota, metabolism, single-cell, and other resources (IDDF2023-ABS-0290 Figure 1. The brief description of IBDIRP). We collect valuable and comprehensive IBD-related data from Pubmed, Google, GMrepo, gutMega, gutMDisorder, Single-cell Portal, etc. We sorted them by systemic reviewing and manually curated them.

Results

We sorted more than 312 unique risk SNPs associated with IBD in the SNP section (IDDF2023-ABS-0290 Figure 2. The-4-major-sections-of-ibdirp (A) is IBD related risk SNPs section). We display over 890 studied IBD-related genes based on the database's collection in the gene section (IDDF2023-ABS-0290 Figure 2. The-4-major-sections-of-ibdirp (B) is IBD related genes section). We show 1116 IBD transcriptomics data on the GEO database. Furthermore, a total of 23,149 taxonomy records were selected from these databases, the sorted IBD-related microbiota data from three primary microbiome databases (GMrepo, gutMega, and gutMDisorder) was available for download (IDDF2023-ABS-0290 Figure 2. The-4-major-sections-of-ibdirp (C,D) is IBD related microbiota section). Specially, we collected 24 IBD-metabolism studies including 2896 participants' in the metabolism section. 4 IBD-related databases were sorted from 10 large single-cell databases and two interactive single-cell data plug-in units are introduced in this section (IDDF2023-ABS-0290 Figure 3. The other 3 section of IBDIRP (B) is IBD single cells data section). The web tool can provide data interaction based on cells and genes. Finally, we listed 18 significant IBD web resources like ECCO and IOIBD websites, IBD scoring tools, IBD genetic and multi-omics resources, IBD biobanks, and other helpful research resources (IDDF2023-ABS-0290 Figure 3. The other 3 section of IBDIRP (A) is the IBD related web sources section). Our lab is also displayed in the web (IDDF2023-ABS-0290 Figure 3. The other 3 section of IBDIRP (C) is IBD related microbiota section).

Conclusions

This IBDIRP website is the first integrated resource for global IBD researchers up to date. Researchers can view the integrated IBD-related knowledge, download the sorted research resources, and link to external resources. Notably, users can get integrated IBD knowledge and help their future research by reinforcing the IBD multi-dimensional impression. Researchers can visit IBDIRP via www.ibdirp.com.