Asymmetric total synthesis of montanine-type amaryllidaceae alkaloids

The first asymmetric total syntheses of (+)-pancratinines B and C and total syntheses of (−)-montanine, (−)-pancracine and (−)-brunsvigine were realized in a divergent fashion. Our synthetic strategy features a copper-catalyzed [3 + 2] annulation reaction and a Pictet–Spengler cyclization.