废止
吲哚
化学
噻唑啉
噻吩
硫黄
范围(计算机科学)
组合化学
插入反应
基质(水族馆)
有机化学
催化作用
计算机科学
海洋学
程序设计语言
地质学
作者
Jing Zheng,Hong Gu,Qinfang Chen,Weiran Yang
摘要
A formal [3 + 2] annulation reaction of crotonate-derived sulfur ylides and β-ketothioamides (KTAs) was successfully developed to produce good-to-excellent yields of thiazoline and spiro[indoline-3,3'-thiophene] scaffolds. This transformation is a powerful tool for the synthesis of thiazoline and spiro[indoline-3,3'-thiophene] scaffolds due to its mild reaction conditions, easily accessible starting materials, and broad substrate scope. A large-scale reaction was carried out to ensure the practical applicability of this methodology. Finally, the plausible mechanistic pathway of the developed methodology was investigated.
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