Efficacy and Safety of Saururus chinensis Extract (LHF618) for Treating Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Study

Allergic rhinitis (AR) has become a global health concern due to its increasing prevalence, significantly impacting the quality of life. Traditional treatment options often provide only temporary symptom relief and may cause adverse effects, leading to the exploration of alternative therapies. This study evaluates the effectiveness and safety of standardized Saururus chinensis extract (LHF618) for alleviating symptoms of AR. Over a 4-week period, patients receiving LHF618 showed significant reductions in total nasal symptom scores, particularly for symptoms such as nasal itching, sneezing, and congestion, compared with the control group. Additionally, LHF618 led to a marked improvement in rhinitis control assessment test scores and a significant reduction in specific immunoglobulin E levels related to dust mite allergens. Importantly, no significant adverse effects were observed, indicating that LHF618 is a well-tolerated and safe option. These findings suggest LHF618 could be a promising natural alternative for managing AR, especially in cases related to dust mite allergies.