内体
内吞循环
内吞作用
溶酶体
细胞生物学
纳米载体
药物输送
细胞内
化学
细胞
生物
生物化学
酶
有机化学
作者
Caian Qiu,Fei Xia,Junzhe Zhang,Qiaoli Shi,Yuqing Meng,Chen Wang,Huanhuan Pang,Li Wei Gu,Chengchao Xu,Qiuyan Guo,Jigang Wang
出处
期刊:Research
[AAAS00]
日期:2023-01-01
卷期号:6
被引量:14
标识
DOI:10.34133/research.0148
摘要
Nanocarriers have therapeutic potential to facilitate drug delivery, including biological agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by several factors; among which, endosomal/lysosomal degradation after endocytosis is the most important. This review summarizes advanced strategies for overcoming endosomal/lysosomal barriers to efficient nanodrug delivery based on the perspective of cellular uptake and intracellular transport mechanisms. These strategies include promoting endosomal/lysosomal escape, using non-endocytic methods of delivery to directly cross the cell membrane to evade endosomes/lysosomes and making a detour pathway to evade endosomes/lysosomes. On the basis of the findings of this review, we proposed several promising strategies for overcoming endosomal/lysosomal barriers through the smarter and more efficient design of nanodrug delivery systems for future clinical applications.
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