甘氨酸受体
代谢受体
代谢型谷氨酸受体7
代谢型谷氨酸受体1
代谢型谷氨酸受体
代谢型谷氨酸受体5
细胞生物学
化学
生物化学
甘氨酸
生物
神经科学
受体
氨基酸
NMDA受体
谷氨酸受体
作者
Thibaut Laboute,Stefano Zucca,Matthew Holcomb,Dipak N. Patil,Chris M Garza,Brittany A. Wheatley,Raktim N. Roy,Stefano Forli,Kirill A. Martemyanov
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2023-03-31
卷期号:379 (6639): 1352-1358
被引量:12
标识
DOI:10.1126/science.add7150
摘要
Glycine is a major neurotransmitter involved in several fundamental neuronal processes. The identity of the metabotropic receptor mediating slow neuromodulatory effects of glycine is unknown. We identified an orphan G protein–coupled receptor, GPR158, as a metabotropic glycine receptor (mGlyR). Glycine and a related modulator, taurine, directly bind to a Cache domain of GPR158, and this event inhibits the activity of the intracellular signaling complex regulator of G protein signaling 7–G protein β5 (RGS7-Gβ5), which is associated with the receptor. Glycine signals through mGlyR to inhibit production of the second messenger adenosine 3′,5′-monophosphate. We further show that glycine, but not taurine, acts through mGlyR to regulate neuronal excitability in cortical neurons. These results identify a major neuromodulatory system involved in mediating metabotropic effects of glycine, with implications for understanding cognition and affective states.
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