Associations between obesity status and cardiovascular disease risk in Chinese community population

Objective To investigate the association between obesity status, self-reported history of cardiovascular diseases(CVD) and CVD risk among community population in Chinese adults. Methods A total of 10 375 subjects aged 40 or older from Jiading Community, Shanghai Municipality were recruited to undergo questionnaire interview, anthropometric measurements and fasting blood sampling. Biochemical features were evaluated and the obesity statuses were categorized according to the Guidelines for Prevention and Control of Overweight and Obesity in Chinese Adults. Subjects were assigned to three groups based on body mass index, and sex-specific analyses was performed. Estimated 10-year Framingham risk for coronary heart disease and 10-year risk for a first hard atherosclerotic cardiovascular diseases(ASCVD) event was calculated. Results Increased body mass index was associated with higher prevalence of self-reported history of CVD, 10-year Framingham risk for coronary heart disease, and 10-year risk for ASCVD. The prevalence of self-reported CVD in male participants with increasing body mass index levels(7.3%, 7.6%, and 11.2% respectively) were higher than in females(6.2%, 7.7%, and 10.6% respectively). Compared with subjects in the normal weight group, those in both overweight and obesity groups had higher 10-year Framingham risk for coronary heart disease and 10-year risk for ASCVD. Male obese participants had increased 10-year Framingham risk for coronary heart disease(OR=2.02, 95%CI 1.50-2.71) and 10-year risk for ASCVD(OR=2.57, 95%CI 1.56-4.22), respectively. Conclusion In Chinese middle-aged and elderly community population, high body mass index was independently associated with increased risk of self-reported history of CVD and 10-year risk for CVD. (Chin J Endocrinol Metab, 2017, 33: 465-472) Key words: Obesity; Cardiovascular diseases; ASCVD risk score; Framingham risk score