Myoblast fusion: Experimental systems and cellular mechanisms

生物 细胞生物学 融合机制 心肌细胞 肌动蛋白 细胞骨架 肌动蛋白细胞骨架 细胞融合 脂质双层融合 细胞粘附 细胞 计算生物学 遗传学
作者
Eyal D. Schejter
出处
期刊:Seminars in Cell & Developmental Biology [Elsevier]
卷期号:60: 112-120 被引量:30
标识
DOI:10.1016/j.semcdb.2016.07.016
摘要

Fusion of myoblasts gives rise to the large, multi-nucleated muscle fibers that power and support organism motion and form. The mechanisms underlying this prominent form of cell-cell fusion have been investigated by a variety of experimental approaches, in several model systems. The purpose of this review is to describe and discuss recent progress in the field, as well as point out issues currently unresolved and worthy of further investigation. Following a description of several new experimental settings employed in the study of myoblast fusion, a series of topics relevant to the current understanding of the process are presented. These pertain to elements of three major cellular machineries- cell-adhesion, the actin-based cytoskeleton and membrane-associated elements- all of which play key roles in mediating myoblast fusion. Among the issues raised are the diversity of functions ascribed to different adhesion proteins (e.g. external cell apposition and internal recruitment of cytoskeleton regulators); functional significance of fusion-associated actin structures; and discussion of alternative mechanisms employing single or multiple fusion pore formation as the basis for muscle cell fusion.
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