微流控
吞吐量
可扩展性
分散性
材料科学
纳米技术
微型反应器
油滴
扩散
工艺工程
化学工程
计算机科学
化学
乳状液
物理
工程类
催化作用
热力学
数据库
高分子化学
电信
无线
生物化学
作者
Tianzhun Wu,Katsuki Hirata,Hiroaki Suzuki,Rong Xiang,Zikang Tang,Tetsuya Yomo
摘要
We report a facile, low-cost, and high-yielding microfluidic technology for in situ generating and arraying water-in-oil droplets by shrinking them to the order of femtolitres (fLs) as scalable batch micro-reactors. Instead of generating ultra-small droplets by the direct atomization, which requires dedicate control and high energy input, we shrink droplets to stable smaller ones by utilizing the controlled water diffusion in oil. This “shrunk to fL” method is combined with a three-dimensional microwell design to create high-density addressable droplet arrays. As the result, scalable, high-throughput, and well-aligned W/O arrays with excellent long-term stability and predicable droplet sizes have been achieved.
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