生物
染色质
计算生物学
核小体
DNA测序
遗传学
核酸酶
基因组学
进化生物学
基因组
DNA
基因
作者
Clifford A. Meyer,X. Shirley Liu
摘要
Next-generation sequencing (NGS) technologies have been used in diverse ways to investigate various aspects of chromatin biology by identifying genomic loci that are bound by transcription factors, occupied by nucleosomes or accessible to nuclease cleavage, or loci that physically interact with remote genomic loci. However, reaching sound biological conclusions from such NGS enrichment profiles requires many potential biases to be taken into account. In this Review, we discuss common ways in which biases may be introduced into NGS chromatin profiling data, approaches to diagnose these biases and analytical techniques to mitigate their effect.
科研通智能强力驱动
Strongly Powered by AbleSci AI