移码突变
终止密码子
线粒体核糖体
核糖体
遗传学
生物
遗传密码
平移移码
线粒体DNA
内啡肽酶
翻译(生物学)
基因
计算生物学
突变
核糖核酸
信使核糖核酸
核糖核酸酶P
作者
Richard Temperley,Ricarda Richter,Sven Dennerlein,Robert N. Lightowlers,Zofia M.A. Chrzanowska-Lightowlers
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2010-01-15
卷期号:327 (5963): 301-301
被引量:154
标识
DOI:10.1126/science.1180674
摘要
Human mitochondria are not strict adherents to the universal genetic code, with modifications that include the apparent recoding of two arginine triplets to termination signals. This use of both AGA and AGG occurs rarely in other mammals, and this putative change has long posed a challenging conundrum. A -1 mitoribosome frameshift upstream of the rare codons would necessitate recognition of only the conventional UAA and UAG termination codons. By using a sequence-specific endoribonuclease, we show that the rare arginine codons, presumably in association with other cis elements, promote frameshifting in human mitoribosomes.
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