Buchwald–Hartwig Reactions of Monohaloflavones

Abstract The article describes the amination of different monobromo‐ or monochloroflavones with primary and secondary alkylamines and aniline derivatives by Buchwald–Hartwig reaction. The influence of the phosphine ligands used is described. The use of amino acid derivatives as a nitrogen source is also demonstrated. This latter reaction allows the synthesis of unique flavone–amino‐acid conjugates.