生存素
有丝分裂
细胞生物学
细胞周期
生物
胞质分裂
凋亡抑制因子
微管
程序性细胞死亡
细胞分裂
癌症研究
细胞
细胞凋亡
遗传学
作者
Fengzhi Li,Grazia Ambrosini,Emily Y. Chu,Janet Plescia,Simona Tognin,Pier Carlo Marchisio,Dario C. Altieri
出处
期刊:Nature
[Springer Nature]
日期:1998-12-01
卷期号:396 (6711): 580-584
被引量:1788
摘要
Progression of the cell cycle and control of apoptosis (programmed cell death) are thought to be intimately linked processes, acting to preserve homeostasis and developmental morphogenesis. Although proteins that regulate apoptosis have been implicated in restraining cell-cycle entry and controlling ploidy (chromosome number), the effector molecules at the interface between cell proliferation and cell survival have remained elusive. Here we show that a new inhibitor of apoptosis (IAP) protein, survivin, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. These results indicate that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.
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