Objective:To compare the quality of Cultivated Scutellaria and Wild Scutellaria in different areas.Methods:Morphological indentification,thin layer chromatography(TLC) and content determination were adopted to compare the quality of Cultivated Scutellaria and Wild Scutellaria.Results:The content of baicalin in medicinal materials of Wild Scutellaria in Neimeng area was the highest,then was in Shanxi and Shan'xi areas,the lowest was the Cultivated Scutellar ia in Neimeng area;and which in decoction pieces of Wild Scutellaria was higher than the Cultivated Scutellaria in Neimeng area.Conclusion:The Cultivated Scutellaria may be in place of Wild Scutellaria.