Role of NFAT in Occurance and Development of Skin Diseases

Nuclear factor of activated T cell(NFAT)is an important factor in cellular signal pathways and was thought to be a in-duced nuclear factor which could Combine and up-regulate IL-2 gene promoter of T cell.It plays a key role in the immune system as well as tumor development and progression.Studies have shown that NFAT is closely related to the occurrence and development of human skin diseases.There is abnormal expression NFAT in derma and Epidermis Components of patients with skin diseases.It activates T cell and promotes autoimmunity formation,even promotes tumor formation and metastasis.This article aims to explain the important role played by NFAT in skin diseases,which involved T cell activation,autoimmunity formation,tumor formation and invasion and metasta-sis,and mechanisms of NFAT in skin diseases.These findings may be of great significance for the treatment of skin diseases.