[Objective]To investigate the clinical application of metal titanic clips for upper gastrointestinal bleeding.[Methods]68 cases of upper gastrointestinal bleeding in Anqing Navy Hospital (including 45 cases of ulcer bleeding ,5 cases of stomach Dieulafoy lesions,12 cases of post-polypectomy and 6 cases of Mallord-Weiss syndrome) were treated by 1~5 metal titanic clips ,the intraoperative and postoperative bleeding were observed.[Results]The initial hemostasis rate of 68 cases was 100%. 8 cases bleed again 48 hours later,of which 6 cases were stanched by metal titanic clips successfully,2 cases of huge ulcer bleeding with treatment failure of metal titanic clips were subsequently treated with operation. The Total effective rate was 97.06%,and without complications of perforation.[Conclusion]The gastroscopy metal titanic clips for upper gastrointestinal bleeding had a good clinical effect.