Gene transfer vector is the important ingredient in gene therapy,which includes virus vector and non-virus vector.At present,the mainly applied virus vectors are retroviral vector,adenovirus vector adenovirus-associated virus slow virus vector,herpes simplex virus vector and so on.Different viruses have their own advantages and disadvantages.With the increasing reform and consummation of virus vector, it can play its important role continuously in gene therapy by promoting its efficacy and safty in gene transfer.