纳米载体
线粒体
药物输送
细胞凋亡
体内
阿霉素
化学
药理学
癌细胞
材料科学
生物物理学
生物化学
纳米技术
生物
癌症
化疗
生物技术
遗传学
作者
Chao Zhang,Zunfeng Liu,Ying Zheng,Yadi Geng,Chao Han,Shi Yamin,Hongbin Sun,Can Zhang,Yijun Chen,Luyong Zhang,Qinglong Guo,Lei Yang,Xiang Zhou,Ling‐Yi Kong
出处
期刊:Small
[Wiley]
日期:2017-12-04
卷期号:14 (4)
被引量:100
标识
DOI:10.1002/smll.201703306
摘要
Abstract Mitochondria‐mediated apoptosis (MMA) is a preferential option for cancer therapy due to the presence of cell‐suicide factors in mitochondria, however, low permeability of mitochondria is a bottleneck for targeting drug delivery. In this paper, glycyrrhetinic acid (GA), a natural product from Glycyrrhiza glabra , is found to be a novel mitochondria targeting ligand, which can improve mitochondrial permeability and enhance the drug uptake of mitochondria. GA‐functionalized graphene oxide (GO) is prepared and used as an effective carrier for targeted delivery of doxorubicin into mitochondria. The detailed in vitro and in vivo mechanism study shows that GA‐functionalized GO causes a decrease in mitochondrial membrane potential and activates the MMA pathway. The GA‐functionalized drug delivery system demonstrates highly improved apoptosis induction ability and anticancer efficacy compared to the non‐GA‐functionalized nanocarrier delivery system. The GA‐functionalized nanocarrier also shows low toxicity, suggesting that it can be a useful tool for drug delivery.
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