Progress of Mannose-binding Lectin-associated Serine Protease 2

MBL-associated serine protease(MASP) and mannan-binding lectin(MBL) are key factors of the lectin pathway of complement activation and play an important role in the defense.MBL or ficolin can form complexes with sugars presented on pathogens through its carbohydrate recognition domain(CRD) and its collagen-like region(CLR) can recognize and binding to MASP.MBL can activity the zymogens of MASP which is a key enzyme and activate the complement cascade through lectin pathway.