癌基因
癌症
生物
癌细胞
代谢途径
信号转导
癌症研究
生物信息学
酶
细胞生物学
遗传学
细胞周期
生物化学
作者
Arvindhan Nagarajan,Parmanand Malvi,Narendra Wajapeyee
标识
DOI:10.1016/j.trecan.2016.06.002
摘要
Oncogenes are key drivers of tumor growth. Although several cancer-driving mechanisms have been identified, the role of oncogenes in shaping metabolic patterns in cancer cells is only beginning to be appreciated. Recent studies show that oncogenes directly regulate critical metabolic enzymes and metabolic signaling pathways. Here, we present evidence for oncogene-directed cancer metabolic regulation and discuss the importance of identifying underlying mechanisms that can be targeted for developing precision cancer therapies.
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