Progress in Visfatin/PBEF/Nampt

Visfatin, exerting insulin-mimetic effects in cultured cells and lowering plasma glucose levels in mice, corresponds to a protein identified previously as pre B cell colony-enhancing factor (PBEF) that expressed in lymphocytes. In addition, Visfatin has also been presumed to be nicotinamide phosphoribosyltransferase(Nampt), synthesizing nicotinamide mononucleotide from nicotinamide in mammalian biosynthetic pathway and is required for Sirt1 activity in vivo.