Effect of atorvastatin with different dosage on plasma level of B-type natriuretic peptide in patients with acute coronary syndrome

Objective To investigate the effect of early intervention by atorvastatin with different dosage on plasma level of B-type natriuretic peptide(BNP) and high sensitive C-reactive protein(hsCRP) in patients with acute coronary syndrome(ACS).Methods Seventy-eight patients with ACS were divided randomly into three groups:atorvastatin group 10 mg(n=28),atorvastatin group 20 mg(n=28),atorvastatin group 40 mg(n=22).All patients took atorvastatin in 24 hours after admission.Blood samples were examined for BNP and hsCRP level at admission and five days after the therapy of atorvastatin in three groups of patients.Results The use of atorvastatin in early admission period of ACS significantly reduced plasma BNP and hsCRP level,the effect which was more obvious in atorvastatin group 20 mg/d and atorvastatin group 40 mg/d than in atorvastatin group 10 mg/d,(543±116) ng/L,(531±112) ng/L vs(738±121) ng/L;(7.02±3.17) mg/L,(6.87±3.21) mg/L vs(9.32±3.43) mg/L(P0.01).The effect of atorvastatin group 40 mg/d was superior to that of atorvastatin group 20 mg/d,but there was no significant difference between them(P0.05).Conclusion The early use of atorvastatin in ACS patients reduces serum BNP and hsCRP level,atorvastatin 40 mg,20 mg/d are better than 10 mg/d.