Synthesis and anti-tuberculosis activity of 2,4-disubstituted quinolines

Synthesis and anti-tuberculosis activity of a new series of 2,4-disubstituted quinolines have been reported. The most promising compounds have been found to exhibit 99% inhibition at 6.25 μg/mL against drug-sensitive M. tuberculosis H37Rv strain and >90% inhibition at 12.5 μg/mL against isoniazid resistant TB strain.