医学
2型糖尿病
二甲双胍
糖尿病
疾病
转化研究
重症监护医学
公共卫生
临床试验
大血管病
儿科
家庭医学
护理部
内科学
内分泌学
病理
作者
Russell Viner,Billy White,Deborah Christie
出处
期刊:The Lancet
[Elsevier]
日期:2017-06-01
卷期号:389 (10085): 2252-2260
被引量:113
标识
DOI:10.1016/s0140-6736(17)31371-5
摘要
Type 2 diabetes in adolescence manifests as a severe progressive form of diabetes that frequently presents with complications, responds poorly to treatment, and results in rapid progression of microvascular and macrovascular complications. Although overall still a rare disease, adolescent type 2 diabetes now poses major challenges to paediatric and adult diabetes services in many countries. Therapeutic options are heavily curtailed by a dearth of knowledge about the condition, with low numbers of participants and poor trial recruitment impeding research. Together with lifestyle modification, metformin remains the first-line therapy for adolescents with type 2 diabetes, although the majority rapidly progress to treatment failure and insulin therapy. Early bariatric surgery is controversial but has great potential to transform outcomes. Health systems must respond by both concentrating patients in specialist clinical services integrated with translational research programmes, but also by joining up with local health and social care services to improve engagement and uptake of services.
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