化学
电泳剂
催化作用
胺化
试剂
酰胺
亲电胺化
基质(水族馆)
功能群
齿合度
氧气
组合化学
药物化学
金属
有机化学
海洋学
聚合物
地质学
作者
Daoming Wang,Daoming Wang,Lei Yang,Dongping Chen,Yichen Wu,Yong Tang,Yong Tang,Peng Wang,Peng Wang,Peng Wang
标识
DOI:10.1021/acs.orglett.4c00285
摘要
O-Acylhydroxylamine has been widely employed as an electrophilic amination reagent in transition-metal-catalyzed C–N coupling reactions, but its use as an electrophilic oxygen source has not been disclosed. Here, we report a Pd-catalyzed 1,2-oxyarylation of alkenes with O-acylhydroxylamines as an oxidant and an oxygen source for the first time. With simple amide as the monodentate directing group, this method features a broad substrate scope, good functional group tolerance, and mild conditions.
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