浸出(土壤学)
草酸
纳米棒
止血
材料科学
坡缕石
化学工程
体内
表面电荷
生物物理学
化学
纳米技术
无机化学
矿物学
粘土矿物
外科
环境科学
土壤科学
工程类
土壤水分
医学
生物技术
物理化学
生物
作者
Yong-zhu Yang,Xiaomei Wang,Yalong Li,Bin Mu,Fangfang Yang,Aiqin Wang,Xinyue Liu
标识
DOI:10.1088/1748-605x/ad407a
摘要
Abstract Palygorskite (Pal) is a naturally available one-dimensional clay mineral, featuring rod-shaped morphology, nanoporous structure, permanent negative charges as well as abundant surface hydroxyl groups, exhibiting promising potential as a natural hemostatic material. In this study, the hemostatic performance and mechanisms of Pal were systematically investigated based on the structural regulate induced by oxalic acid (OA) gradient leaching from perspectives of structure, surface attributes and ion release. In vitro and in vivo hemostasis evaluation showed that Pal with OA leaching for 1 h exhibited a superior blood procoagulant effect compared with the raw Pal as well as the others leached for prolonging time. This phenomenon might be ascribed to the synergistic effect of the intact nanorod-like morphology, the increase in the surface negative charge, the release of metal ions (Fe3+ and Mg2+), and the improved blood affinity, which promoted the intrinsic coagulation pathway, the fibrinogenesis and the adhesion of blood cells, thereby accelerating the formation of robust blood clots. This work is expected to provide experimental and theoretical basis for the construction of hemostatic biomaterials based on clay minerals.
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