聚合物囊泡
变构调节
药物输送
材料科学
纳米技术
生物物理学
纳米医学
纳米颗粒
化学
聚合物
生物化学
生物
复合材料
共聚物
两亲性
酶
作者
Yu Zheng,Yang Liu,Zijian Wu,Peng Chen,Zuojie Wang,Jiajie Yan,Yue Yan,Zifen Li,Congcong Liu,Jianxin Xue,Hong Tan,Qiang Fu,Mingming Ding
标识
DOI:10.1002/adma.202210986
摘要
Abstract Allosteric transitions can modulate the self‐assembly and biological function of proteins. It remains, however, tremendously challenging to design synthetic allosteric polymeric assemblies with spatiotemporally switchable hierarchical structures and functionalities. Here, a photoallosteric polymersome is constructed that undergoes a rapid conformational transition from β‐sheet to α‐helix upon exposure to near‐infrared light irradiation. In addition to improving nanoparticle cell penetration and lysosome escape, photoinduced allosteric behavior reconstructs the vesicular membrane structure, which stimulates the release of hydrophilic cytolytic peptide melittin and hydrophobic kinase inhibitor sorafenib. Combining on‐demand delivery of multiple therapeutics with phototherapy results in apoptosis and immunogenic death of tumor cells, remold the immune microenvironment and achieve an excellent synergistic anticancer efficacy in vivo without tumor recurrence and metastasis. Such a light‐modulated allosteric transition in non‐photosensitive polymers provides new insight into the development of smart nanomaterials for biosensing and drug delivery applications.
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