表观遗传学
生物
DNA甲基化
同型半胱氨酸
高同型半胱氨酸血症
组蛋白
遗传学
染色质
后生
机制(生物学)
生物信息学
计算生物学
DNA
基因
生物化学
基因表达
认识论
哲学
作者
Cheng-Yan Wu,Xulei Duan,Xuehui Wang,Libo Wang
出处
期刊:Epigenomics
[Future Medicine]
日期:2023-08-01
卷期号:15 (15): 769-795
标识
DOI:10.2217/epi-2023-0207
摘要
Homocysteine has a wide range of biological effects. However, the specific molecular mechanism of its pathogenicity is still unclear. The diseases induced by hyperhomocysteinemia (HHcy) are called homocysteine-related diseases. Clinical treatment of HHcy is mainly through folic acid and B-complex vitamins, which are not effective in reducing the associated end point events. Epigenetics is the alteration of heritable genes caused by DNA methylation, histone modification, noncoding RNAs and chromatin remodeling without altering the DNA sequence. In recent years the role of epigenetics in homocysteine-associated diseases has been gradually discovered. This article summarizes the latest evidence on the role of epigenetics in HHcy, providing new directions for its prevention and treatment.
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