Synthesis of Polysubstituted Pyrimidines through Palladium-Catalyzed Isocyanide Insertion to 2H-Azirines

The domino process of the palladium-catalyzed coupling reaction of isocyanides with 2 H -azirine provides various tetrasubstituted pyrimidines via one C–C bond and two C–N bond formations with satisfactory yields. The title compounds are obtained with good functional group tolerance, high atom economy, and broad substrate scopes.