肌萎缩
医学
优势比
混淆
置信区间
入射(几何)
队列研究
物理疗法
风险因素
队列
内科学
逻辑回归
人口
物理
环境卫生
光学
作者
Nicola Veronese,Ai Koyanagi,Mario Barbagallo,Ligia J. Domínguez,Stefania Maggi,Pınar Soysal,Francesco Bolzetta,Giovanni Ruotolo,Alberto Castagna,Lee Smıth
出处
期刊:The Journals of Gerontology
[Oxford University Press]
日期:2023-02-20
卷期号:78 (6): 1013-1019
被引量:5
标识
DOI:10.1093/gerona/glad062
摘要
Abstract Background Pain and sarcopenia are common in older people. Cross-sectional studies have reported a significant association between these two conditions, but cohort studies exploring pain as a potential risk factor for sarcopenia are scarce. Given this background, the aim of the present work was to investigate the association between pain (and its severity) at baseline, and the incidence of sarcopenia over 10 years of follow-up in a large representative sample of the English older adult population. Methods Pain was diagnosed using self-reported information and categorized as mild to severe pain at four sites (low back, hip, knee, and feet). Incident sarcopenia was defined as having low handgrip strength and low skeletal muscle mass during the follow-up period. The association between pain at baseline and incident sarcopenia was assessed using an adjusted logistic regression analysis, and reported as odds ratios (ORs) with their 95% confidence intervals (CIs). Results The 4 102 participants without sarcopenia at baseline had a mean ± standard deviation age of 69.7 ± 7.2 years, and they were mainly male (55.6%). Pain was present in 35.3% of the sample. Over 10 years of follow-up, 13.9% of the participants developed sarcopenia. After adjusting for 12 potential confounders, people with pain reported a significantly higher risk of sarcopenia (OR = 1.46: 95% CI: 1.18–1.82). However, only severe pain was significantly associated with incident sarcopenia, without significant differences across the four sites assessed. Conclusions The presence of pain, particularly severe pain, was associated with a significantly higher risk of incident sarcopenia.
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