生物
干细胞
祖细胞
再生(生物学)
细胞生物学
重编程
肝再生
再生医学
祖细胞
免疫学
平衡
细胞
生物化学
作者
Atsushi Miyajima,Minoru Tanaka,Tohru Itoh
出处
期刊:Cell Stem Cell
[Elsevier]
日期:2014-05-01
卷期号:14 (5): 561-574
被引量:456
标识
DOI:10.1016/j.stem.2014.04.010
摘要
The liver is a central organ for homeostasis with unique regenerative capacities. Mature hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to discern the role of adult liver stem cells in this process. In contrast, stem/progenitor cells in the developing liver have been extensively characterized, and these investigations have informed efforts to produce functional hepatocytes in vitro for cell therapy and drug screening. In this Review, we describe recent advances in the characterization of liver stem cells and discuss evidence supporting and refuting whether self-renewable and bipotential liver stem cells exist in development, homeostasis, regeneration, and disease.
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