甘薯糖苷
鬼臼毒素
依托泊苷
拓扑异构酶
木脂素
癌症化疗
计算生物学
化学
拓扑异构酶抑制剂
药理学
生物
癌症
生物化学
化疗
立体化学
遗传学
酶
出处
期刊:Biochimie
[Elsevier]
日期:1998-03-01
卷期号:80 (3): 207-222
被引量:324
标识
DOI:10.1016/s0300-9084(98)80004-7
摘要
This review deals with the historical discovery of particularly important lignan derivatives used in cancer chemotherapy. From isolation of the naturally occurring podophyllotoxin, an inhibitor of microtubule assembly, to hemisynthesis of the clinically important anticancer drugs etoposide and teniposide, it will be demonstrated how the activities and the ability of this class of compounds to inhibit topoisomerase II were discovered by different research teams. By virtue of these discoveries, new hemisynthetic derivatives, with different mechanisms of action, are bringing improvements in the ability to treat cancer.
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