线粒体融合
线粒体
生物
功能(生物学)
DNAJA3公司
细胞生物学
计算生物学
线粒体DNA
粒线体疾病
遗传学
基因
作者
Brittany N. Whitley,E.A. Engelhart,Suzanne Hoppins
出处
期刊:Mitochondrion
[Elsevier]
日期:2019-11-01
卷期号:49: 269-283
被引量:106
标识
DOI:10.1016/j.mito.2019.06.002
摘要
Mitochondrial dynamics shape the mitochondrial network and contribute to mitochondrial function and quality control. Mitochondrial fusion and division are integrated into diverse cellular functions and respond to changes in cell physiology. Imbalanced mitochondrial dynamics are associated with a range of diseases that are broadly characterized by impaired mitochondrial function and increased cell death. In various disease models, modulating mitochondrial fusion and division with either small molecules or genetic approaches has improved function. Although additional mechanistic understanding of mitochondrial fusion and division will be critical to inform further therapeutic approaches, mitochondrial dynamics represent a powerful therapeutic target in a wide range of human diseases.
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