Circadian control of mitochondrial dynamics and functions

Physiology and behavior in mammals is predominantly under circadian clock control. Circadian clocks are present in nearly every cell of the body and oscillate with a frequency of about 24 h in a self-sustained and cell autonomous manner. These clocks not only play a principal role in metabolic control but concurrently respond to a wide variety of metabolic cues. While various aspects of circadian regulation of metabolic functions have been extensively studied, our knowledge regarding circadian mitochondrial biology is just emerging. We review herein the current literature addressing circadian mitochondrial biology: from diurnal changes in mitochondrial make-up, through dynamics and functions. We will discuss as well potential mechanisms that are implicated in circadian control of mitochondrial biology in mammals.