Slippery liquid-infused microphase separation surface enables highly robust anti-fouling, anti-corrosion, anti-icing and anti-scaling coating on diverse substrates

• SLIPS is facilely constructed on various substrates and shapes in bulk. • The microphase separation on the surface enables ultra-stable oil-locking ability. • SLIPS can resist biofouling and alleviate inflammation response in vivo . • SLIPS enables highly robust anti-corrosion, anti-icing and anti-scaling properties. • SLIPS demonstrates potential in the field of biomedical and industrial applications. Slippery liquid-infused porous surface (SLIPS) strategy has demonstrated great potential in the field of both biomedical and industrial applications. However, the fabrication of large-area SLIPS with a combined competence of strong bonding to diverse substrates as well as robust oil-locking ability especially those with special shape and structure remains highly challenging. Herein, SLIPS was facilely constructed on various substrates and shapes in bulk via a step-by-step deposition strategy. Collective results demonstrated that the facile and feasible formation of SLIPS coating implemented the combination of multiple excellent properties, including anti-fouling, anti-corrosion, anti-icing, anti-scaling, and readily self-healing. In particular, the spontaneous microphase separation on the surface induced by the prominent polar differences between the superhydrophobic fluorinated segments and hydrophilic hydroxyl and amino groups enabled ultra-stable oil-locking ability, ensuring high robustness under conditions of blood flow, in vivo transplantation, hydrodynamic shear stress even accompanied with boiling and ultrasound, and mechanical wear. Therefore, such desirable properties will endow this SLIPS coating strategy promising practical applications in surgical equipment, medical implants, marine and industrial facilities.