酸敏离子通道
神经科学
神经退行性变
小胶质细胞
离子通道
星形胶质细胞
生物
神经胶质
胶质瘤
细胞生物学
炎症
中枢神经系统
免疫学
医学
病理
疾病
癌症研究
受体
生物化学
作者
Victoria Cegielski,Rohan Chakrabarty,Shinghua Ding,Michael Wacker,Paula Monaghan‐Nichols,Xiang‐Ping Chu
出处
期刊:Membranes
[MDPI AG]
日期:2022-01-20
卷期号:12 (2): 119-119
被引量:7
标识
DOI:10.3390/membranes12020119
摘要
Acid-sensing ion channels (ASICs) are proton-gated cation channels and key mediators of responses to neuronal injury. ASICs exhibit unique patterns of distribution in the brain, with high expression in neurons and low expression in glial cells. While there has been a lot of focus on ASIC in neurons, less is known about the roles of ASICs in glial cells. ASIC1a is expressed in astrocytes and might contribute to synaptic transmission and long-term potentiation. In oligodendrocytes, constitutive activation of ASIC1a participates in demyelinating diseases. ASIC1a, ASIC2a, and ASIC3, found in microglial cells, could mediate the inflammatory response. Under pathological conditions, ASIC dysregulation in glial cells can contribute to disease states. For example, activation of astrocytic ASIC1a may worsen neurodegeneration and glioma staging, activation of microglial ASIC1a and ASIC2a may perpetuate ischemia and inflammation, while oligodendrocytic ASIC1a might be involved in multiple sclerosis. This review concentrates on the unique ASIC components in each of the glial cells and integrates these glial-specific ASICs with their physiological and pathological conditions. Such knowledge provides promising evidence for targeting of ASICs in individual glial cells as a therapeutic strategy for a diverse range of conditions.
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