Advances in protective effect of HSP70/HSP27 on immune cells

As an important kind of nonspecific cytoprotective proteins,heat shock proteins(HSPs) play a vital role in the stress tolerance and stress protection of immune cells,acting as molecular chaperones or anti-apoptosis effects in the maintenance of the immune cells survival and the stability of the internal environment.HSP70 and HSP27 of small heat shock proteins(sHPSs),an important member of HSPs,have been proved to have significant effect on mediating the cell proliferation,differentiation and apoptosis process.In this paper,the protective effect of HSP70/HSP27 on immune cells under the condition of heat stress was reviewed.