Changes of serum osteocalcin and β-cross laps in patients with hyperthyroidism before and after treatment

Objective To investigate the changes of bone metabolism markers in patients with hyperthyroidism before and after treatment and the characteristics of bone turnover rate.Methods Forty-six patients with hyperthyroidism and thirty healthy controls were included into this study.Electrochemical luminescence immunoassay(ECLIA) method was used to measure serum osteocalcin and β-cross laps levels in all the hyperthyroid patients before and after antithyroid (methimazole) therapy and thirty healthy volunteers.Results The mean concentrations of both osteocalcin and β-cross laps in hyperthyroid patients before and after treatment were significantly higher than those in the healthy subjects (P0.000),increased by 1.74 folds and 1.80 folds respectively before treatment and 2.26 folds and 2.16 folds respectively after treatment.The correlation analysis showed that the serum FT3 was positively correlated with osteocalcin(P0.05) and FT4 was positively correlated with osteocalcin and β-cross laps (P0.05) before methimazole treatment.The serum osteocalcin was positively correlated with β-cross laps (P0.01) as well.Compared with the untreated hyperthyroidism group,serum osteocalcin and β-cross laps were further increased after methimazole treatment for 2 months (P0.05).Conclusions High bone turnover rate characterizes the bone metabolism in the patients with hyperthyroidism.The activity of bone may dominant with osteoclast resulting in abnormal bone metabolism in the untreated hyperthyroidism patients.However,in the patients who under treatment,both bone resorption and bone formation were further increased and bone formation were more prominent,which suggested that the osteoblast activity dominant the whole progress in favor of bone remodeling.