P2X2/NR2B: a new ionotropic receptor complex

Event Abstract Back to Event P2X2/NR2B: a new ionotropic receptor complex Ricardo J. Rodrigues1, Antonio Domingues2, Ana Cristina-Rego2*, Rodrigo A. Cunha2 and Juan Lerma1 1 CSIC-UMH, Instituto de Neurociencias de Alicante , Spain 2 University of Coimbra, Center for Neuroscience and Cell Biology of Coimbra., Portugal In the nervous system, fast signalling is achieved by activation of ligand-gated ion channels. Previous studies have reported a tight interaction and cross-talk between ionotropic receptors, namely between P2XRs and other ionotropic receptors such as nAChRs, 5-HT3Rs and GABAARs. These interactions are all characterised by a physical interaction that leads to an activity-dependent cross-inhibition designed to negatively control the excess of function of other fast signalling systems by ATP. Since P2X and NMDA receptors are coincidence detectors of neuronal function, a putative dimerization between P2X and NMDA receptors would be of particular interest. This hypothesis is prompted by the observations that ATP and glutamate are co-released from nerve terminals and P2XRs and NMDARs have an overlapping subcellular localization in the CNS.We now report the existence of hybrid P2X2/NR2B receptors, ionotropic receptors composed by subunits from dissimilar receptor families that are able to sense more than one signalling molecule. Indeed, NMDA (300 Conference: 11th Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 4 Jun - 6 Jun, 2009. Presentation Type: Oral Presentation Topic: Symposium 1– Neuronal Communication Citation: Rodrigues RJ, Domingues A, Cristina-Rego A, Cunha RA and Lerma J (2009). P2X2/NR2B: a new ionotropic receptor complex. Front. Neurosci. Conference Abstract: 11th Meeting of the Portuguese Society for Neuroscience. doi: 10.3389/conf.neuro.01.2009.11.009 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 Aug 2009; Published Online: 05 Aug 2009. * Correspondence: Ana Cristina-Rego, University of Coimbra, Center for Neuroscience and Cell Biology of Coimbra., Alicante, Portugal, ricardojrodrigues@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ricardo J Rodrigues Antonio Domingues Ana Cristina-Rego Rodrigo A Cunha Juan Lerma Google Ricardo J Rodrigues Antonio Domingues Ana Cristina-Rego Rodrigo A Cunha Juan Lerma Google Scholar Ricardo J Rodrigues Antonio Domingues Ana Cristina-Rego Rodrigo A Cunha Juan Lerma PubMed Ricardo J Rodrigues Antonio Domingues Ana Cristina-Rego Rodrigo A Cunha Juan Lerma Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.