Role of retinal pigment epithelium in age-related macular disease: a systematic review

视网膜色素上皮 医学 视网膜 眼科 黄斑变性 疾病 视网膜 验光服务 眼病 病理 神经科学 生物
作者
Alan C. Bird
出处
期刊:British Journal of Ophthalmology [BMJ]
卷期号:105 (11): 1469-1474 被引量:27
标识
DOI:10.1136/bjophthalmol-2020-317447
摘要

Age-related macular disease (AMD) is a major cause of blindness and there is little treatment currently available by which the progress of the basic disorder can be modulated. Histological and clinical studies show that the major tissues involved are the outer retina, retinal pigment epithelium, Bruch’s membrane and choroid. Because of a wide variation of phenotype from one case to another, it has been suggested that accurate phenotyping would be necessary for assessment of the effectiveness of treatment that is tissue-directed. However, based on findings from the study of human donor material and animal models of disease and of cell culture, it is concluded that retinal pigment epithelial dysfunction plays a central role in the disease process in most, if not all, cases of early AMD. The metabolism of phagosomal material, particularly lipids, and energy generation are interdependent, and dysfunction of both appears to be important in the genesis of disease. Evidence exists to suggest that both can be modulated therapeutically. These metabolic functions are amenable to further investigation in both the normal state and in disease. Once fully characterised, it is likely that treatment could be directed towards a limited number of functions in single tissue, thus simplifying treatment strategies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
量子星尘发布了新的文献求助10
2秒前
2秒前
Bazinga发布了新的文献求助10
2秒前
思源应助theway采纳,获得10
4秒前
7秒前
orixero应助美好柚子采纳,获得10
8秒前
脑洞疼应助lin1j采纳,获得50
8秒前
优美元枫完成签到,获得积分10
9秒前
晓天发布了新的文献求助10
10秒前
hushan53发布了新的文献求助10
11秒前
小马过河应助飞飞采纳,获得30
13秒前
今后应助科研通管家采纳,获得10
15秒前
上官若男应助科研通管家采纳,获得10
15秒前
oboy应助科研通管家采纳,获得10
15秒前
yznfly应助科研通管家采纳,获得30
15秒前
15秒前
15秒前
15秒前
共享精神应助Cheryy采纳,获得10
18秒前
19秒前
无花果应助cgx采纳,获得30
20秒前
量子星尘发布了新的文献求助10
20秒前
闪闪的乐蕊完成签到,获得积分10
21秒前
22秒前
23秒前
24秒前
24秒前
大蜥蜴完成签到,获得积分10
27秒前
美好柚子发布了新的文献求助10
27秒前
27秒前
王欣完成签到 ,获得积分10
27秒前
爱睡觉发布了新的文献求助10
28秒前
Cheryy发布了新的文献求助10
30秒前
美好柚子完成签到,获得积分10
33秒前
充电宝应助曹兆采纳,获得10
33秒前
科研通AI5应助曹兆采纳,获得10
33秒前
彭于晏应助曹兆采纳,获得30
33秒前
bkagyin应助曹兆采纳,获得100
33秒前
Andy完成签到,获得积分10
35秒前
littleknees发布了新的文献求助10
35秒前
高分求助中
【提示信息,请勿应助】请使用合适的网盘上传文件 10000
Continuum Thermodynamics and Material Modelling 2000
The Oxford Encyclopedia of the History of Modern Psychology 1500
Green Star Japan: Esperanto and the International Language Question, 1880–1945 800
Sentimental Republic: Chinese Intellectuals and the Maoist Past 800
The Martian climate revisited: atmosphere and environment of a desert planet 800
Learning to Listen, Listening to Learn 520
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3867145
求助须知:如何正确求助?哪些是违规求助? 3409400
关于积分的说明 10663430
捐赠科研通 3133586
什么是DOI,文献DOI怎么找? 1728284
邀请新用户注册赠送积分活动 832879
科研通“疑难数据库(出版商)”最低求助积分说明 780510