一元羧酸盐转运体
甲状腺
激素
运输机
有机阴离子转运多肽
生物
内分泌学
医学
内科学
生物化学
基因
作者
Stefan Groeneweg,Ferdy S van Geest,Robin P. Peeters,Heike Heuer,Willy Visser
出处
期刊:Endocrine Reviews
[The Endocrine Society]
日期:2019-11-22
卷期号:41 (2): 146-201
被引量:108
标识
DOI:10.1210/endrev/bnz008
摘要
Abstract Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion transporting polypeptide (OATP) 1C1, and SLC17A4 are currently known as transporters displaying the highest specificity toward thyroid hormones. Structure-function studies using homology modeling and mutational screens have led to better understanding of the molecular basis of thyroid hormone transport. Mutations in MCT8 and in OATP1C1 have been associated with clinical disorders. Different animal models have provided insight into the functional role of thyroid hormone transporters, in particular MCT8. Different treatment strategies for MCT8 deficiency have been explored, of which thyroid hormone analogue therapy is currently applied in patients. Future studies may reveal the identity of as-yet-undiscovered thyroid hormone transporters. Complementary studies employing animal and human models will provide further insight into the role of transporters in health and disease.
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