Adipolin and Insulin Resistance Response to Two Types of Exercise Training in Type 2 Diabetic Male Rats

Introduction: Adipolin (CTRP12), which improves insulin sensitivity, is a novel antiinflammatory adipocytokine secreted from adipose tissue.In this study we aimed to assess the Adipolin and Insulin Resistance index (HOMA-IR) response to two types of exercise in type 2diabetic male rats. Materials and methods:In this study, 24diabetic Wistar rats (Induced by high-fat diet and Intraperitoneal injection Streptozotocin (stz) injection) were randomly assigned to 3groups: High intensity interval training (HIIT), low intensity continuous training (LICT) and control (C).Both training groups were trained on the treadmill, 5 sessions per week for 8 weeks.Blood samples were taken 24hours after the end of training session and plasma adipolin, insulin and glucose levels were measured.ANOVA and Tukey post hoc tests were used to analyze data and the level of significance was considered to be p≤05.Results: Data analysis showed that plasma adipolin levels in the low intensity continuous training group were significantly increased, compared to the control group (p=0.006).Plasma glucose level in both the low intensity continuous training and the high intensity interval groups was significantly decreased, compared to the control group (p=0.049)& (p=0.007).Plasma insulin level in both training groups was increased and HOMA-IR index was decreased, compared to the control group, although changes were not significant. Conclusion:The results of this study showed that exercise training can increase plasma adipolin in rats with type 2diabetes, changes however that are partially dependent on the type of exercise training Keywords: high intensity interval training, low intensity continous training, adipolin, insulin resistance, type 2 diabetes