Effect of ginkgo-dipyridamolum(GLEDI) on TGF-β_1 expression in the renal of type 2 diabetic nephropathy rats

Objective To investigate the effect of ginkgo-dipyridamolum(GLEDI) on type 2 diabetes nephropathy rats(2-DN) and the expression of TGF-β1 in 2-DN rats renal.Methods The Wistar rats were randomly divided into diabetic model,diabetic model treated with GLEDI and normal control groups.At the end of 12 weeks,the protein expression and secretion of TGF-β1 was determined by immunohistochemistry,Furthermore blood glucose,blood lipid,blood urea nitrogen(BUN) and blood creatinine(SCr) were measured.Results The tratio of renal weight / body weight,and the level of BUN and Scr of diabetic model group and GLEDI treated group were significantly higher than those of normal control group(P0.01).The tratio of renal weight / body weight and the level of BUN and Scr of GLEDI treated group were siginificantly lower than those of diabetic model group(P0.01).The expression of TGF-β1 protein in diabetic model group and GLEDI treated group were siginificantly higher than that of normal control group,and TGF-β1 protein in treatment group was lower than that of diabetic model group.Conclusions Ginkgo-dipyridamolum has renal protective effect on 2 DN rats by reducing the expression of TGF-β1 of renal tissue.