多囊卵巢
内科学
医学
内分泌学
接收机工作特性
前瞻性队列研究
病例对照研究
胰岛素抵抗
胰岛素
作者
Fatma Nurgül Taşgöz,Nergis Kender Ertürk,Tayfur Çift
出处
期刊:Biomarkers
[Informa]
日期:2022-04-19
卷期号:27 (5): 483-487
标识
DOI:10.1080/1354750x.2022.2064549
摘要
To analyse the SFRP-5 serum levels in PCOS and to investigate the relationship between SFRP-5 and other metabolic parameters in PCOS.This is a prospective case-control study carried out in a research hospital. A total of 88 subjects including 43 patients diagnosed PCOS according to Rotterdam criteria and age -BMI matched 45 healthy controls were evaluated. Serum SFRP5, fasting blood glucose, insulin levels and HOMA-IR scores of the groups were determined and compared. The cut-off of SFRP-5 for detecting PCOS was calculated.Serum SFRP-5 levels were lower in PCOS group compared to the controls (290.13 ± 187.66 ng/mL vs 533.03 ± 208.55 ng/mL, p < 0.001). There was no correlation in the PCOS group regarding SFRP-5 and other parameters. The role of SFRP-5 to predict the PCOS risk was assessed with receiver operating curve (ROC). The sensitivity of SFRP-5 was 74.4% and the specificity was 75.6% at a threshold ≤388.38 ng/ml in PCOS.SFRP-5 could be a beneficial marker for PCOS diagnosis, follow-up and treatment.
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