Identifying clinical, biological, and quality of life variables associated with depression, anxiety, and fatigue in pSS and sicca syndrome patients: a prospective single-centre cohort study

• Depressed pSS patients have more fatigue, and less health and social functioning. • In pSS, general fatigue was associated with increased pain and IL5 levels. • In pSS, lower motivation fatigue increased with age and Flt-3 ligand levels. • In sicca syndrome , depression, anxiety, and fatigue were not associated with variables.