细胞生物学
程序性细胞死亡
细胞
自噬
细胞凋亡
生物
坏死性下垂
小型GTPase
癌细胞
细胞培养
癌症研究
细胞生长
细胞内
化学
电池类型
上睑下垂
信号转导
癌症
生物化学
遗传学
作者
Oliver Florey,Kim Se,Michael Overholtzer
出处
期刊:Current Molecular Medicine
[Bentham Science]
日期:2015-11-05
卷期号:15 (9): 861-866
被引量:25
标识
DOI:10.2174/1566524015666151026100042
摘要
Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in epithelial cell cultures and human tumors. Entotic cells control their own engulfment, by invading into their hosts in a Rho-GTPase and actomyosin-dependent manner. Although entotic cells are internalized while alive, most eventually undergo a non-apoptotic form of cell death, called entotic cell death, that is executed non-cell-autonomously by autophagy proteins and lysosomes. Here we review the current understanding of entosis and entotic cell death and discuss the potential roles of this process in cancer.
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