吗啡
睾酮(贴片)
内分泌学
内科学
麻醉药
精囊
萎缩
医学
性器官
生理学
前列腺
药理学
生物
麻醉
遗传学
癌症
作者
Theodore J. Cicero,Edward R. Meyer,Walter G. Wiest,John W. Olney,Roy D. Bell
出处
期刊:PubMed
日期:1975-03-01
卷期号:192 (3): 542-8
被引量:12
摘要
The effects of chronic morphine administration on a variety of rat organs were examined. Only the prostates and seminal vesicles were affected by a 3-day period of morphine pellet implantation. In these organs, particularly the seminal vesicles, morphine produced a marked decrease in both the wet and dry tissue weight and a reduction in their secretory activity. This apparent morphine-induced atrophy of these important accessory sex organs was not due to a change in the nutritional status of the animals but rather appeared to be associated with a pronounced (87 percent) reduction in the serum testosterone levels of morphine-treated rats when compared to control levels. The effect of morphine on the secondary sex organs was reversed by withdrawing the animals from morphine administration for a period of 7 days. These data suggest that the role of physiological and endocrinological factors in the narcotic addict's sexual difficulties be examined.
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